Personal Data
Name Saghi Sepehri
Field of specialization Medicinal Chemistry 
Academic rank Assistant professor
Email s.sepehri@pharmacy.arums.ac.ir
Phone number +98 45 335 224 37-39 (125)

(Update: December 2018)

Degree

Field of specialization

Name of institution attended

 Year of graduation

PhD Candidate

Medicinal Chemistry

Faculty of Pharmacy, Isfahan University of Medical Sciences

2016

MSc

Organic Chemistry

Faculty of Chemistry, Isfahan University of Technology

2007

BSc

Applied Chemistry

Faculty of Chemistry, Shahreza University

2004

 

Degree

 Title of thesis

Supervisors

Score

PhD

Design, synthesis and biological evaluation of some possible HIV-1 fusion inhibitors as
novel anti-AIDS

Dr. Afshin Fassihi (Associate Professor), Dr. Hamid Reza Memariyan (Full Professor), Dr. Lotfollah Saghaie (Full Professor), Mohammad Reza Aghasadeghi (Full Professor)

19.96
(highest score of phD thesis defense - Isfahan University of Medical Science)

MSc

Synthesis and characterization of polyamides derived from phthalic anhydride and L-phenylalanine under microwave irradiation in ionic liquid and aromatic polyesters based on
5-(S)-[4-(4-methyl-2-phthalimidylpentanoyl-amino)benzoylamino]isophtha;ic acid

Dr. Shadpour Mallakpour (Full Professor)

 19.50

Title

Year

Design, synthesis and evaluation of cytotoxic, antimicrobial, and anti-HIV-1 activities of new 1,2,3,4-tetrahydropyrimidine derivatives
N Razzaghi-Asl,  M Kamrani-Moghadam, B Farhangi, RVahabpour, R Zabihollahi, S Sepehri
Research in Pharmaceutical Sciences, 14 (2),155-166

2019

Anti-cancer, anti-oxidant and molecular docking studies of thiosemicarbazone indole-based derivatives
Z Bakherad
M SafaviA FassihiH Sadeghi-AliabadiM BakheradH RastegarJ B. GhasemiS SepehriL Saghaie, M Mahdavi
Research on Chemical Intermediates, in press

2019

Synthesis of New Derivatives of 1, 2, 3‐Triazole‐Linked Phthalazine‐1, 4‐dione in Water: Experimental Aspects and Molecular Docking Calculations
Mohammad Bakherad, Saeed Karami, Ali Keivanloo, S Sepehri
ChemistrySelect, 3 (39), 11042-11047

2018

Salophen copper(II) complex‐assisted click reactions for fast synthesis of 1,2,3‐triazoles based on 1,4‐naphthoquinone scaffold, anti‐bacterial evaluation and molecular docking studies
Sima Abbaspour, Ali Keivanloo, Mohammad Bakherad, S Sepehri
Chemistry & Biodiversity

2018

Identification of COX-2 inhibitors via structure-based virtual screening and molecular dynamics simulation
Nima Razzaghi-Asl, Sahar Mirzayi, Karim Mahnam, S Sepehri
Journal of  Molecular Graphics and Modelling, 83, 138-152

2018

Design, Synthesis and Anti-HIV-1 Evaluation of a Novel Series of 1,2,3,4-Tetrahydropyrimidine-5-carboxylic acid Derivatives
S Sepehri, S Soleymani, R Zabihollahi, MR Aghasadeghi, M Sadat, L Saghaie, HR Memarian, A Fassihi
Chemistry & Biodiversity, Online publish, 15 (4), 1700502

2018

Synthesis, Biological Evaluation and Molecular Docking Studies of Novel 4‐Arylpyridin‐1 (4H)‐yl) benzoic acid Derivatives as Anti‐HIV‐1 Agents
S Sepehri, S Soleymani, R Zabihollahi, MR Aghasadeghi, M Sadat, L Saghaie, A Fassihi
Chemistry & Biodiversity, 14 (12), 1-14

2017

Anti‐HIV‐1 Activity Prediction of Novel Gp41 Inhibitors Using Structure‐Based Virtual Screening and Molecular Dynamics Simulation
S Sepehri, L Saghaie, A Fassihi
Molecular informatics, 36 (3)

2017

Response surface methodology in drug design: A case study on docking analysis of a potent antifungal fluconazole
F Bohlooli, S Sepehri, N Razzaghi-Asl
Computational Biology and Chemistry, 67, 158-173

2017

Integrating docking and molecular dynamics approaches for a series of proline-based 2, 5-diketopiperazines as novel αβ-tubulin inhibitors
N Fani, AK Bordbar, Y Ghayeb, S Sepehri
Journal of Biomolecular Structure and Dynamics, 33 (10), 2285-2295

2015

Molecular docking and quantum mechanical studies on biflavonoid structures as BACE-1 inhibitors
N Razzaghi-Asl, S Sepehri, A Ebadi, R Miri, S Shahabipour
Structural Chemistry, 26 (2), 607-621

2015

QSAR and docking studies of some 1, 2, 3, 4-tetrahydropyrimidines: evaluation of gp41 as possible target for anti-HIV-1 activity
S Sepehri, S Gharagani, L Saghaie, MR Aghasadeghi, A Fassihi
Medicinal Chemistry Research, 24 (4), 1707-1724

2015

Computational design of Tryprostatin-A derivatives as novel αβ-tubulin inhibitors
N Fani, AK Bordbar, Y Ghayeb, S Sepehri
Journal of Biomolecular Structure and Dynamics, 33 (3), 471-486

2015

Hantzsch-type dihydropyridines and biginelli-type tetra-hydropyrimidines: a review of their chemotherapeutic activities
S Sepehri, HP Sanchez, A Fassihi
Journal of Pharmacy & Pharmaceutical Sciences, 18 (1), 1-52

2015

Effect of biomolecular conformation on docking simulation: a case study on a potent HIV-1 protease inhibitor
N Razzaghi-Asl, S Sepehri, A Ebadi, R Miri, S Shahabipour
Iranian journal of pharmaceutical research: IJPR, 14 (3), 785

2015

Novel 9-(alkylthio)-Acenaphtho [1, 2-e]-1, 2, 4-triazine derivatives: synthesis, cytotoxic activity and molecular docking studies on B-cell lymphoma 2 (Bcl-2)
MK Mohammadi, O Firuzi, M Khoshneviszadeh, N Razzaghi-Asl, S Sepehri
DARU Journal of Pharmaceutical Sciences, 22 (1), 2

2014

Synthesis and characterization of new optically active polyesters by step‐growth polymerization of novel aromatic (2S)‐4‐[(4‐methyl‐2‐phthalimidyl‐pentanoylamino) benzoylamino] isophthalic acid with aromatic diols
S Mallakpour, S Sepehri
Journal of applied polymer science, 110 (5), 2942-2949

2008

Polycondensation of new optically active diacid with diisocyanates in the presence of tetrabutylammonium bromide as a green media under microwave heating
S Mallakpour, S Sepehri
Reactive and Functional Polymers, 68 (10), 1459-1466

2008

Preparation of new optically active polyamides containing a L-phenylalanine, phthalimide side-chain via the diisocyanate route by microwave energy: comparison with conventional heating
S Mallakpour, S Sepehri
Designed Monomers and Polymers, 11 (6), 535-546

2008

  •  Research Projects
No.

                                                                                Title

                  Institute

 Approval  
      year 

completion 
       year 

 Implementation 
plan

1

Identification and comparison of  the effect of lead compounds as Novel COX-2 inhibitors by computational techniques in drug design

Ardabil university of Medical  Sciences       2017
  

      2018

        Executor

 

  • Synthesis of potential pharmaceutical compounds
  • Structure activity relationship of synthesized potential pharmaceutical compounds
  • Optimization of synthesis methods using novel techniques and green chemistry
  • Design of potential novel pharmaceutical compounds by molecular docking simulation
  • Introduction of potential novel pharmaceutical compounds and prediction of their biological effects using Virtual Screening, Drug likeness, PASS and ADMET methods
  • Investigation of compounds interactions with target proteins using molecular dynamics simulation

Title

 Year

Top researcher of Ardabil University of Medical Sciences

2019

Third rank in faculties section of 23rd festival of the Quran and the enodus of health ministry

2018

 

Title

Place

No

Molecular dynamic simulation & its application in medicinal chemistry

School  of Pharmacy, Ardabil University of Medical Sciences

2018

Molecular dynamic simulation & its application in medicinal chemistry

School  of Pharmacy, Ardabil University of Medical Sciences

2017

Molecular dynamic simulation & its application in medicinal chemistry

School  of Pharmacy, Ardabil University of Medical Sciences

2016

Poster design

Faculty of Pharmacy, Isfahan University of Medical Sciences

2014

Specialized scientific search

Faculty of Pharmacy, Isfahan University of Medical Sciences

2014

Preparation for PhD exam in Medicinal Chemistry

Faculty of Pharmacy, Isfahan University of Medical Sciences

2013

Specialized scientific search

Faculty of Pharmacy, Isfahan University of Medical Sciences

2012